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Cells enriched from heterogenous tumors by cell sorting can be used upstream of the ResolveDNA TM chemistry to concomitantly improve the sensitivity of variant allele detection.
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Follow us and learn more about life at Beckman Coulter Diagnostics. 29 days ago Internal Communications Coordinator Senior Medical Writer. Pier-Luc Plante, Director, Implementations for North America Commercial Operations Service, working remotely and based in Jeffersonville, Indiana. For Research: Past Remote and Flexible Jobs at Beckman Coulter Executive Assistant. Join this webinar to learn how ResolveDNA TM chemistry can be used to study allelic variation at a single-cell resolution. At Beckman Coulter, we see the results when teams unleash their potential through open ways of thinking, working and living. The ResolveDNA TM amplification utilizes primary template-directed amplification (PTA) to overcome each of these shortcomings, providing unprecedented accuracy in single nucleotide variation (SNV) and copy number variation (CNV) calling. About Careers Terms & Conditions Privacy Policy Cookie Policy. Single-cell analysis provides the fundamental unit of resolution to define this evolution, but existing methods to amplify the genomes of single cells suffer from poor genomic coverage, uniformity, and allelic balance. Roche (13), BioNTech (12), Beckman Coulter Life Sciences (11), Eurofins (11). A comprehensive picture of somatic cell clonal evolution driving tumorigenesis is not possible with bulk sequencing strategies that fail to uncover rare alleles.